It is a sign of South Africa's injury crisis and rapid evolution that just nine of their 23-man squad have ever faced Nigeria before.
2019 ScheduleAll times ET
Nigeria may be in pole position in Group E, but they're up against it in Johannesburg if they're to avoid a repeat of recent unhappy memories.
KweséESPN reviews the performances of Nigerian players across the European leagues at the weekend.
KweséESPN breaks down Nigeria's available options in goal and at centre-forward ahead of the all-important qualifying clash against South Africa.
KweséESPN looks at five talking points for South Africa ahead of the crunch AFCON qualifier against Nigeria next weekend.
Odion Ighalo tells KweséESPN he is "devastated and sad" after suffering an injury that has effectively ended his season.
The NFF find themselves in the news for the wrong reasons after Super Falcons players traveled to camp in their own clothes instead of team kit.
Galatasary forward Henry Onyekuru has been called up from the standby list to replace Odion Ighalo ahead of Nigeria's AFCON qualifier vs Bafana.
If preparation, organisation, and motivation were the measures of champions, one might as well surrender the 2018 Africa Women Cup of Nations to SA.
Defending champions Nigeria named their squad of 21 for the upcoming Africa Women Cup of Nations, which kicks off in Ghana later this month.
The Toffees' fringe players comfortably dispatched K'Ogalo in the Sportpesa Cup.
Nigeria find themselves in a goalkeeping pickle as they prepare to face South Africa in an upcoming Africa Cup of Nations qualifier.
Nigeria goalkeeper Francis Uzoho will miss the Super Eagles' 2019 Africa Cup of Nations qualifier against South Africa due to injury.
South Africa's decision to take their Nations Cup qualifier against Nigeria to FNB Stadium is a boost to their chances of reaching the finals.
In this round-up, KweséESPN reviews the performances of Nigerian players across European leagues over the weekend,
After being handed his maiden Nigeria call-up, KweséESPN profiles Villarreal wonderkid Samuel Chukwueze.
Gernot Rohr's selection of Adeleye Olamilekan may have been a response to critics of his usual policy, but it could just lead to more problems.
Wilfred Ndidi's late caution against Libya in Sfax, his second yellow card in three days, was the first midfield-related bad omen...
Ikouwem Udoh's aspirations of capping a sensational year with a maiden Nigeria call-up went up in smoke on Monday, as coach Rohr left him sidelined.
Veteran midfielder John Obi Mikel's omission from the Nigeria squad to face South Africa is at the player's own request, says coach Gernot Rohr.
Charleroi's Victor Osimhen has been recalled to the 23-man Nigeria squad for next month's Africa Cup of Nations qualifier against South Africa.
Three months can make a whole world of difference in the career of a professional footballer, and that is the case for the in-form Victor Osimhen.
KweséESPN reviews the performances of Nigerian players at the weekend, with a good number finding the back of the net across Europe's top leagues.
It has taken 10 appearances, eight of those as a substitute, but Isaac Success finally got his first Premier League goal of the season on Saturday.