Francesco Caputo celebrated a goal in Sassuolo's win over Brescia by holding a sign that read "Everything will be alright, stay at home."
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Sassuolo scored three goals in the first 26 minutes as they upset 10-man Roma 4-2, for their first-ever win over the capital club.
Napoli ended an eight-match winless run in Serie A and gave new coach Gennaro Gattuso his first victory on Sunday.
AC Milan had a goal chalked off by VAR, missed an open goal, were foiled by the goalkeeper and twice hit the woodwork in a draw against Sassuolo.
Cristiano Ronaldo scored his first Juventus goal since October to rescue a draw against Sassuolo, as the Bianconeri dropped points.
All 20 clubs from Serie A have written a joint open letter to ask for help in dealing with the issue of racism.
Substitute Felipe Caicedo scored a stoppage-time goal as Lazio claimed a fifth successive Serie A win by beating lowly Sassuolo 2-1 away on Sunday.