The Dukes (6-3, 4-2 Colonial Athletic Association), ranked third in the FCS, outgained UNH 486-315, but had six turnovers, including four interceptions while the Wildcats were turnover-free and had five sacks.
Trevor Knight added two touchdown passes and a 75-yard scramble up the middle to make it 35-10 in the fourth quarter for the Wildcats (3-6, 2-4), who opened the season with four losses.
A James Madison fumble on a strip-sack by Quinlen Dean led to a 29-yard touchdown pass from Knight to Kieran Presley before Ellison returned an interception for a 44-yard pick-6 and a 14-0 lead. Horn snared a pass in the flat and returned it 75 yards and UNH led 21-3 at the half.
Knight finished with 181 yards passing and 76 rushing.
Cole Johnson was 31-of-48 passing for 398 yards but no scores and three picks while the Dukes rushed for only 64 yards.
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