McNeese (3-3, 1-2 Southland) built a 24-3 lead with 5 1/2 minutes to play before halftime. The Lions rallied before intermission when Chason Virgil threw a 10-yard TD pass to C.J. Turner. Southern Louisiana (3-3, 2-1) forced a three-and-out and scored again when backup quarterback Cole Kelley threw a 31-yard score to Lorenzo Nunez to reduce the deficit to 24-17.
The Lions cut it to 24-20 with a field goal before they took their first lead when Virgil threw a 60-yard scoring pass to Nunez early in the fourth quarter.
Mack ran for 142 yards on 28 carries and scored twice.
Virgil finished with 321 yards passing and Kelley threw for two scores for the Lions.
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