South Dakota took a 48-45 edge in the third overtime on a Mason Lorber 27-yard field goal before Boyle started his team off with a 15-yard rush, then hit Hendrix three plays later for the winning touchdown.
Boyle finished with 193 yards and five touchdowns passing and 187 yards and two scores rushing for the Sycamores (5-4, 3-3 Missouri Valley Football Conference). Titus McCoy added 123 yards rushing. Hendrix had 111 yards and two touchdowns receiving.
Indiana State led 21-14 at halftime and took a 31-24 lead with 2:54 remaining in regulation on a 25-yard run by Boyle. But Austin Simmons took the Coyotes (3-6, 2-4) 81 yards in 13 plays after that, capping the drive with an 11-yard touchdown pass to Brett Samson to even it up with 16 seconds left and force overtime.
Simmons had 375 yards and three touchdowns passing for the Coyotes.
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