Guadagni appeared to hurt his shoulder late in the second quarter and Peters opened the third with a 34-yard touchdown pass on a flea flicker to Reggie Gilliam for a 30-17 lead. Western Michigan fumbled on its next possession, and Peters found Cody Thompson for an 18-yard touchdown for a 20-point advantage.
Peters threw for 107 yards for Toledo (4-4, 2-2 Mid-American Conference). Guadagni was 10-of-18 passing for 140 yards and two touchdowns. Jameson Vest made three second-quarter field goals to move into second on Toledo's career list with 67.
Freshman Kaleb Eleby threw for 293 yards and two touchdowns in his debut for Western Michigan (6-3, 4-1), which had its six-game winning streak snapped.
Western Michigan wore special helmets, with a pink stripe down the middle, in support of breast cancer awareness.
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