Sources have told ESPN the money generated from that transfer has fast-tracked their interest in Dest if a suitable transfer fee can by agreed between the clubs.
Dest, 19, is regarded as one of the world's best young right-backs and has been on the radar of a number of top clubs this summer.
Barcelona manager Ronald Koeman is a long-standing admirer of Dest, and when Netherlands coach, was keen on him to declare for the Oranje but Dest, after much deliberation, opted to play for the United States.
But with Odriozola's loan up, they are looking to bolster with Dest, which would allow Joshua Kimmich to leave his previous duties at fullback behind to focus on his role in the midfield.
Information from ESPN Barcelona correspondents Sam Marsden and Moises Llorens was used in this report