Two men with contrasting comeback stories will press their World Cup claims when a new-look Wallabies host Argentina in Brisbane on Saturday.
Playmaker Christian Lealiifano will make a remarkable return following his battle with leukaemia while reformed talent James O'Connor is set to come off the bench and end a six-year Test hiatus at Suncorp Stadium.
Ending a three-year Wallabies absence, playmaker Lealiifano will join Will Genia, Marika Koroibete and Kurtley Beale as additions to the starting backline just four Tests out from September's World Cup in Japan.
"As usual he downplays everything," Cheika said of Lealiifano's reaction to his call-up ahead of regular five-eighth Bernard Foley, who is not part of the match-day squad.
"Selection's one thing but I really want to see him succeed in this position here and be a strong part of this team going into the World Cup and I'll do everything I can as the coach to help him make it."
O'Connor, now 29, has attracted his share of negative press for off-field antics since his Wallabies debut as an 18-year-old.
Back on Rugby Australia's books after signing with the Queensland Reds, O'Connor has impressed Cheika and will provide versatility in a finishing role at his home stadium.
"(His selection is) based off the back of his form over there (with English club Sale) that's when I approached him and ... he's made a lot happen himself to get back here," Cheika said.
"He's made sacrifices - first world sacrifices mind you, not third world - but he really wants it, to play footy for his country and do it well."
In all there are five changes to the team that started in last weekend's loss to South Africa in Johannesburg and a further five changes on the bench.
But Samu Kerevi will again partner Tevita Kuridrani in the monster centre pairing used against the Springboks, with Cheika hinting Kuridrani would be given more opportunities in a tweaked game plan.
Beale replaces Tom Banks at fullback after his brilliant cameo off the bench at Ellis Park and back-up lock Luke Jones eyes his first Test since 2014.
Scott Sio returns from injury to start while fellow prop James Slipper has recovered from his nasty head knock against the Springboks and drops to the bench.
Argentina came within a whisker of defeating New Zealand at home (20-16) last weekend and upset the Wallabies on the Gold Coast last year.
But victories like that have been rare for the Pumas, who are on the six-game losing streak and watched as Australia orchestrated their biggest comeback win in Test history against them in Salta last year.
Wallabies: Kurtley Beale, Reece Hodge, Tevita Kuridrani, Samu Kerevi, Marika Koroibete, Christian Lealiifano, Will Genia, Isi Naisarani, Michael Hooper (capt), Lukhan Salakai-Loto, Rory Arnold, Izack Rodda, Sekope Kepu, Folau Faingaa, Scot Sio. Replacements: Tolu Latu, James Slipper, Taniela Tupou, Rob Simmons, Luke Jones, Nic White, Matt Toomua, James O'Connor.