Manning, 39, is the only player in franchise history to suit up for 16 seasons, and his 236 regular-season games (234 starts) and 248 total games are both Giants records. He is sixth in NFL history with 8,119 attempts and seventh with 4,895 completions, 57,023 yards and 366 touchdown passes.
He leaves the game on an elite list with Bart Starr, Terry Bradshaw, Joe Montana and Tom Brady as the only players with at least two Super Bowl MVPs.
Manning, who was set to become a free agent this offseason, has made more than $250 million from his football contracts, the most in NFL history.
His father, Archie, had long said he never thought Eli would play for another team. He will not, despite taking a month after the conclusion of the season to make his final decision.
Since news of Manning's retirement broke on Wednesday, his former teammates, coaches and others from the NFL have weighed in via social media on the departure of the two-time Super Bowl winner.
Congratulations on your retirement, and a great career Eli! Not going to lie though, I wish you hadn't won any Super Bowls.— Tom Brady (@TomBrady) January 24, 2020
Congratulations to one of the fiercest competitors the league has ever seen. Man of the Year, Super Bowl champion, philanthropist, and ambassador for the game...the game won't be the same without you my friend.#ThankYouEli pic.twitter.com/8VXoKYRrB1— Larry Fitzgerald (@LarryFitzgerald) January 23, 2020
Thank you #10!! My teammate and brother forever! pic.twitter.com/UWCPJbJxkX— Michael Strahan (@michaelstrahan) January 24, 2020
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Congrats Eli on your retirement. 16 years of constant performance, reliability, humility, and passion to make those people around you better. My hat is off to you. I know how hard it is to show up everyday in the good and bad and be looked upon to lead and you did it better than anyone I've seen. You deserve all the praise coming your way and more. You embodied everything that's good about this sport and will be remembered as one of the best to do it on and off the field. #10 #HOF
Congratulations, Eli. pic.twitter.com/KjjYyWbRo5— Roger Goodell (@nflcommish) January 23, 2020
Congrats to Eli Manning on a great career. Much respect for him as a player, competitor and person. True legend of the game.— Kirk Cousins (@KirkCousins8) January 23, 2020
Eli Manning's retirement press conference is taking place in the Giants field house to accommodate the expected large crowd. Never in my 8 years covering the team have I seen a setup like this in the field house. The auditorium wouldn't have provided enough room for this farewell pic.twitter.com/h8UP9DG6S9— Jordan Raanan (@JordanRaanan) January 24, 2020
Congrats on a great career Eli.— Terrell Thomas (@TerrellThomas24) January 22, 2020
"That's my quarterback" TO voice https://t.co/h32NiOxmE7