Isaac is believed to have been hurt in Orlando's win Sunday against the Celtics. He was struck in the jaw and experienced concussion-like symptoms after the game, leading the Magic to put him in the protocol.
Orlando coach Steve Clifford had said earlier Thursday that he had no idea when Isaac would be cleared. The second-year forward, the Magic's first-round pick (sixth overall) in 2017, is averaging 9.6 points and 5.5 rebounds this season.
Magic leading scorer and rebounder Nikola Vucevic, who missed Wednesday night's regular-season finale because of a stomach virus, said he felt better Thursday and expected to face the Raptors in Game 1 on Saturday (5 p.m., ESPN).