Bayer Leverkusen LEV v |  Rangers RAN | TBD | | |
| 2nd Leg - Bayer Leverkusen lead 3-1 on aggregate |
FC Basel BAS v |  Eintracht Frankfurt EINF | TBD | | |
| 2nd Leg - FC Basel lead 3-0 on aggregate |
FC Copenhagen COP v |  Istanbul Basaksehir IST | TBD | | |
| 2nd Leg - Istanbul Basaksehir lead 1-0 on aggregate |
Internazionale INT v |  Getafe GET | TBD | | |
Manchester United MAN v |  LASK Linz LAS | TBD | | |
| 2nd Leg - Manchester United lead 5-0 on aggregate |
Sevilla FC SEV v |  AS Roma ROMA | TBD | | |
Shakhtar Donetsk SHAK v |  VfL Wolfsburg WOLF | TBD | | |
| 2nd Leg - Shakhtar Donetsk lead 2-1 on aggregate |
Wolverhampton Wanderers WOLV v |  Olympiakos OLY | TBD | | |
| 2nd Leg - Tied on aggregate |