Brayan Angulo Tenorio gave Cruz Azul the lead twice in the first half, and the Mexican side powered to a 3-1 win over Toronto FC in the first leg of their CONCACAF Champions League quarterfinal in Tampa.
The second leg is scheduled for May 4 in Mexico City.
A curling 18-yard effort from Angulo in the third minute opened the scoring, but Toronto's Jonathan Osorio leveled the score in the 20th minute after a scramble in the six-yard box.
Angulo put Cruz Azul on top for good in the 34th minute with a tap-in off a corner kick. Pablo Aguilar's header off a free kick in the 58th minute sealed the first-leg outcome.