Many of Pep Guardiola's squad are back at the Etihad Campus on Monday after being given time off for the international break.
De Bruyne has not played since injuring his hamstring in the victory over Bournemouth on March 2 and missed Belgium's European Championship qualifiers against Russia and Cyprus. Stones injured his groin and was withdrawn from the England squad for the Euro 2020 victory over the Czech Republic and Monday night's game in Montenegro.
Brazil international Fernandinho is also on his way back after being out for more than a month after also suffering a groin injury in the Carabao Cup final triumph over Chelsea on Feb. 24.
The trio could feature at Craven Cottage with a busy period upcoming as City compete for the Premier League and face Champions League games against Tottenham as well as an FA Cup semifinal against Brighton.
Guardiola, who took a break ahead of the final months of the season as City try to win an unprecedented quadruple, said he "prayed" to have his players back fit ahead of the international break.