Tim Cahill one of six first-team Socceroos set to miss England friendly

A string of new faces, including A-League players, could line up for the Socceroos against England later this month, with up to half a dozen regulars almost certain to be absent.

Coach Ange Postecoglou will name his squad on Wednesday for the May 27 friendly at Sunderland's Stadium of Light.

But he probably won't include Chinese Super League stars Matthew Spiranovic, Ryan McGowan, Trent Sainsbury, Apostolos Giannou and Tim Cahill, all of whom are unlikely to be released from their clubs given the match which does not fall on a FIFA date.

Winger Mathew Leckie is also unavailable due to pre-planned family commitments.

Postecoglou will therefore look to others to fill the hole against Roy Hodgson's full-strength England side, and faces a big decision on who to install in the striker role in the absence of Cahill and Giannou.

Brisbane spearhead Jamie Maclaren has been close to selection for some time and may finally get his chance, with Netherlands-based Tomi Juric shaping as another option, though the 24-year-old hasn't scored since returning from his long injury layoff.

Young Adelaide United midfielder Stefan Mauk and just-departed winger Craig Goodwin could also be in Postecoglou's sights, while likely recalls include Melbourne City midfield star Aaron Mooy, Perth right-back Josh Risdon and Sydney FC centre-back Alex Wilkinson.

Any A-League draftees will face the challenge of staying fit more than a month after they last played, in stark contrast to England who will have finished the Premier League season less than two weeks prior and will be gearing up for Euro 2016.

The circumstances will force Postecoglou to name a very different squad again next week for the Socceroos' two home friendlies against Greece, that fall mere days after the England clash but within FIFA dates.

Leckie will be available and the China-based group also free to feature, however Massimo Luongo has already ruled himself out of both fixtures with the 23-year-old midfielder's wife due to give birth to the couple's first child.