1 p.m. ET | FOX
Matchup rating: 47.1 | Spread: TB -9 (48.5)
What to watch for: The Bucs fell short in their quest to go toe-to-toe with the Saints last week, but since his first career start in 2001, Tom Brady has a career 48-13 record coming off a loss (.787 win percentage), second only to that of Russell Wilson. Panthers coach Matt Rhule said it himself: "No one's better at bouncing back from a loss than Tom Brady." But what about Mike Evans? Can he rebound from his one-catch performance? And how quickly can a Panthers' defense that started four rookies last Sunday make progress in Week 2? -- Jenna Laine
Bold prediction: The Panthers will sack Brady at least five times and pull off an upset. They were one of three teams that did not get a sack in their opener and the only team that didn't contact the quarterback while running or throwing. But coach Matt Rhule says he wants them to get more violent at the point of attack. -- David Newton
Stat to know: Both of Brady's interceptions last week came when throwing within 2.5 seconds of the snap, per NFL Next Gen Stats. He had three such picks in all of 2019.
What to know for fantasy: The Bucs held Christian McCaffrey to 7.3 points in Week 2 last season. Since then, he has joined Emmitt Smith (23), Marcus Allen (17) and Todd Gurley (15) as the only running backs to score at least 15 fantasy points in 15 straight games. See Week 2 rankings.
Newton's pick: Panthers 34, Buccaneers 24
Laine's pick: Buccaneers 28, Panthers 21
FPI prediction: TB, 72.5% (by an average of 8.5 points)
Matchup must-reads: Anderson hilariously mistakes Panthers mascot for a bear ... Arians on Favre's critique: Brady and I are 'fine' ... Rhule takes blame for not calling McCaffrey's number ... Is it time to reset expectations on Bucs after disappointing start? ... Godwin not worried: Bucs learning life with Brady