1 p.m. ET | CBS
Matchup rating: 46.5 | Spread: NE -6.5 (43)
What to watch for: While all eyes will be on Cam Newton becoming the first non-homegrown quarterback to start for the Patriots since Scott Secules in Week 10 of the 1993 season, equally as compelling will be the matchup between Dolphins wide receiver DeVante Parker and Patriots cornerback Stephon Gilmore (assuming both play through hamstring injuries). Parker got the best of Gilmore -- the NFL's Defensive Player of the Year -- in last year's season finale (8 catches, 137 yards) in a performance that sat with Gilmore all offseason. -- Mike Reiss
Bold prediction: Preston Williams -- not Parker -- leads the Dolphins in receiving, totaling over 100 yards in his first game back from a torn ACL. Parker was the star of the last matchup between these two teams. But with a healthy duo and extra attention of Parker, Williams will be the main beneficiary of Ryan Fitzpatrick's aggressive downfield throws. -- Cameron Wolfe
Stat to know: Newton will become fifth quarterback to make his first start for the Patriots since coach Bill Belichick became the team's head coach. The previous four all won that first start.
What to know for fantasy: After getting shut out in Week 2 against the Patriots, Parker's 137 receiving yards in Week 17 were the most against the Patriots since Tyreek Hill's 142 in Week 6 of 2018. See Week 1 rankings.
Betting nugget: Miami was 9-3 ATS over the final 12 games last season, all as an underdog. Read more.
Wolfe's pick: Patriots 20, Dolphins 16
Reiss' pick: Patriots 24, Dolphins 20
FPI prediction: NE, 70.3% (by an average of 7.7 points)
Matchup must-reads: Why Fitzpatrick's impact on Dolphins cannot be overstated ... New era: Newton ends Patriots' QB streak, takes over for Brady ... Dolphins 2020 season preview: It's Fitzpatrick's team, until Tagovailoa takes over ... Patriots 2020 season preview: Can Newton keep dynasty rolling? ... Dolphins acquire Raiders' dynamic RB Bowden