1 p.m. ET | CBS
Matchup rating: 43.2 | Spread: BUF -5.5 (41)
What to watch for: In two games against the Dolphins in 2019, Bills quarterback Josh Allen completed 62.7% of his passes for 458 yards, five touchdowns and zero interceptions, along with 11 rushes for 88 yards and a touchdown. We should keep an eye on whether that success continues against a revamped Dolphins defense, which now includes former Bills edge rusher Shaq Lawson but still gave up 217 rushing yards last week to the Patriots -- including 75 yards to Cam Newton. -- Cameron Wolfe
Bold prediction: The Bills will have two 100-yard receivers on Sunday. They ran a four-receiver set on a league-high 25% of their snaps last week, and despite the Dolphins' struggles against the run in Week 1, the Bills will commit once again to their passing game. -- Marcel Louis-Jacques
Stat to know: The Dolphins had 87 rushing yards in Week 1, and they had 13 games with fewer than 100 rushing yards last season (tied for the most in the NFL with the Jets).
What to know for fantasy: Allen has multiple touchdown tosses nine times in his career, and he is 4-for-4 against the Dolphins and 5-for-25 against the rest of the NFL. See Week 2 rankings.
Betting nugget: The Bills have covered four straight games as the favorite. Read more.
Louis-Jacques' pick: Bills 31, Dolphins 17
Wolfe's pick: Bills 27, Dolphins 16
FPI prediction: BUF, 65.3% (by an average of 5.6 points)