It's probably one of the most anticipated London derbies for quite some time, despite the fact both sides aren't playing great football.
West Ham host Tottenham with the latter now under the guidance of Jose Mourinho after Mauricio Pochettino was given his marching orders earlier in the week.
I fancy Spurs will be one of those teams that 'bounce back' immediately after a change in manager, which happens quite often these days. For them to win though, they need to arrest a slump in away performances with their current streak of 12 fixtures without a win concerning.
Recent history also points to a Tottenham win here with five of the past six derbies won by the away team. West Ham secured the points earlier this calendar year by becoming the first team to win at Tottenham's new home ground.
The Hammers have fallen off a cliff after having a decent start to the season, dropping four of their past five games and drawing the other. Confidence is low, form is poor, and they face a team which should arrive with some renewed vigour.
It is Spurs for mine in this clash, but you're taking take a short price. Outside of backing them outright, Harry Kane is the man for goal scorer bets as he has 28 goals in 45 London derbies - only Thierry Henry, Teddy Sheringham and Frank Lampard have more.
After an eventful clash against the Pittsburgh Steelers on Thursday Night Football last week, the Cleveland Browns will be aiming to stretch their winning run to three games when they host the Miami Dolphins at FirstEnergy Stadium on Monday morning.
The Browns were able to secure a 21-7 home win over their AFC North division rival to keep their playoffs hopes alive. However, the victory was overshadowed by defensive end Myles Garrett hitting Steelers quarterback Mason Rudolph in the head with Rudolph's helmet in the dying seconds.
Despite the offseason acquisition of Odell Beckham Jr, the Browns offence has failed to fire, and they will be under increased pressure with the defence now missing their best player in Garrett.
The Dolphins have experienced a terrible season; evident by their 2-8 record. However, they have won two of their last three games and after losing their first four games by an average of 34.25 points, their last four defeats have been by an average of 10.25 points per contest.
The Dolphins have only allowed 30 or more points twice in their last six games (both against the Buffalo Bills) and that should allow them to stay close with the Browns, who have struggled offensively for most of this season.
Miami might not defeat Cleveland, but they should remain within striking distance.
Seattle Seahawks are desperate to overtake San Francisco 49ers in the pursuit of the NFC West division title and they will be aiming to maintain the pressure with a win against the Philadelphia Eagles at Lincoln Financial Field on Monday morning.
The Seahawks (8-2 record) enjoyed their bye week after beating the 49ers 27-24 on the road in Week 10. In a tremendous tussle, Jason Myers kicked a 42-yard field goal as time expired in overtime to end San Francisco's dream of an unbeaten regular season.
Quarterback Russell Wilson is one of the regular season MVP contenders with 23 touchdown passes and only two interceptions. Wilson's performance has been the catalyst for the Seahawks winning three straight games and six of their last seven.
The Eagles fell one game behind the Dallas Cowboys in the race for the NFC East division crown with their 17-10 home loss to the New England Patriots. The Eagles struggled to run the ball, which placed the burden on quarterback Carson Wentz, who only completed 50 percent of his passes.
After throwing 12 touchdown passes in the Eagles' first six games, Wentz has thrown four touchdowns in the last four games. His struggles mirror the Eagles' poor play against playoff-calibre teams. Philadelphia's last three losses have been against the Patriots, Cowboys (Week 7) and Minnesota Vikings (Week 6).
The Seahawks have been more consistent than the Eagles this season and they appeal as slight outsiders.