England will be without wing Jack Nowell and flanker Sam Underhill and could also be missing captain Dylan Hartley and prop Harry Williams when they take on France on Saturday.
Eddie Jones and his side saw their hopes of a Six Nations Grand Slam dashed in Scotland two weeks ago and are regrouping for a trip to take on the French in Paris.
Nowell has picked up an ankle problem while promising back row Underhill is unavailable due to a toe injury. Forwards coach Steve Borthwick also confirmed hooker Hartley is struggling to overcome a leg muscle issue ahead of the game.
Better news for Jones comes in the form of the return to fitness of versatile three-quarter Elliot Daly, who is back in full training after ankle and calf issues, while Saracens' Jamie George -- a starter for the British & Irish Lions on last year's tour of New Zealand -- is set to make a rare start should Hartley miss out.
Borthwick said: "Dylan and Harry will be monitored on a daily basis and we'll see how that progresses.
"Dylan trained yesterday (Monday) and felt a bit of tightness afterwards. He reported that and the decision of the medical team is to monitor it daily. It's meant that Luke Cowan-Dickie was called up to the squad yesterday and trained fully this morning as cover.
"We have the two hookers in Dylan and Jamie and we need the third hooker as cover. And Kyle Sinckler is here as a tighthead prop as well as those are specialist positions so you need specialist cover."