The Panthers (4-1) scored 24 straight points after trailing the Lions 10-3 early in the second quarter. Detroit rallied, but could not stop Newton on his last drive to get the ball back.
Newton came under fire for making sexist comments to a female reporter this week. He apologized after losing an endorsement deal and getting criticized by the NFL.
He was 26 of 33 for a season-high 335 yards. On perhaps the game's key play, he converted a third-and-19 from the Carolina 24 with a sharp, 17-yard pass to Kelvin Benjamin with 2:00 left while clinging to a three-point lead against a team out of timeouts.
Newton threw a 6-yard TD pass to rookie Christian McCaffrey to pull the Panthers into a 10-10 tie early in the second quarter and a 10-yard pass to Devin Funchess for a tiebreaking score with 48 seconds left in the first half. With a perfectly lofted 31-yard pass to Benjamin, the 2015 NFL MVP put Carolina up 24-10 early in the third.
Detroit (3-2) struggled to move the ball in the air and on the ground until late in the game.
Matthew Stafford, limping after being sacked several times and hit on other plays, threw a 4-yard TD pass to Darren Fells with 5:56 left and a 20-yard pass for a score to the former professional basketball player with 3:22 to go.
TAKING A BREAK
Charlotte Observer reporter Jourdan Rodrigue was not working in the Ford Field press box during the Panthers-Detroit Lions game.
"Taking some time off," Mike Persinger, the executive sports editor of The Charlotte Observer, wrote in an email.
Rodrigue asked Cam Newton about wide receiver Devin Funchess' route running on Wednesday and Carolina's quarterback laughed and said, "It's funny to hear a female talk about routes. It's funny."
Panthers: Cornerback Daryl Worley had an ankle injury.
Lions: Defensive tackle Haloti Ngata had an elbow injury.
Panthers: Host Philadelphia on Thursday night.
Lions: Play at New Orleans next Sunday.
For more NFL coverage: http://www.pro32.ap.org and http://www.twitter.com/AP-NFL
Chris Mortensen and Adam Schefter share why the league is veering away from automatic ejections for targeting.
Charles Woodson and Matt Hasselbeck debate if Steelers safety Mike Mitchell is a dirty player.
Giants quarterback Eli Manning arrives at MetLife Stadium, where he'll be back in the starting lineup for New York's game against Dallas.
Giants interim coach Steve Spagnuolo talks about the team's decision to make Eli Manning their starting quarterback once again.
Adam Schefter breaks down the NFL draft outlook for Baker Mayfield, saying the Oklahoma QB will be selected higher than many people may think.
Adam Schefter explains how the Browns' rush to hire John Dorsey has led the Giants to former Panthers GM Dave Gettleman.