The Panthers (4-1) scored 24 straight points after trailing the Lions 10-3 early in the second quarter. Detroit rallied, but could not stop Newton on his last drive to get the ball back.
Newton came under fire for making sexist comments to a female reporter this week. He apologized after losing an endorsement deal and getting criticized by the NFL.
He was 26 of 33 for a season-high 335 yards. On perhaps the game's key play, he converted a third-and-19 from the Carolina 24 with a sharp, 17-yard pass to Kelvin Benjamin with 2:00 left while clinging to a three-point lead against a team out of timeouts.
Newton threw a 6-yard TD pass to rookie Christian McCaffrey to pull the Panthers into a 10-10 tie early in the second quarter and a 10-yard pass to Devin Funchess for a tiebreaking score with 48 seconds left in the first half. With a perfectly lofted 31-yard pass to Benjamin, the 2015 NFL MVP put Carolina up 24-10 early in the third.
Detroit (3-2) struggled to move the ball in the air and on the ground until late in the game.
Matthew Stafford, limping after being sacked several times and hit on other plays, threw a 4-yard TD pass to Darren Fells with 5:56 left and a 20-yard pass for a score to the former professional basketball player with 3:22 to go.
TAKING A BREAK
Charlotte Observer reporter Jourdan Rodrigue was not working in the Ford Field press box during the Panthers-Detroit Lions game.
"Taking some time off," Mike Persinger, the executive sports editor of The Charlotte Observer, wrote in an email.
Rodrigue asked Cam Newton about wide receiver Devin Funchess' route running on Wednesday and Carolina's quarterback laughed and said, "It's funny to hear a female talk about routes. It's funny."
Panthers: Cornerback Daryl Worley had an ankle injury.
Lions: Defensive tackle Haloti Ngata had an elbow injury.
Panthers: Host Philadelphia on Thursday night.
Lions: Play at New Orleans next Sunday.
For more NFL coverage: http://www.pro32.ap.org and http://www.twitter.com/AP-NFL
John Harbaugh explains the defensive schemes the Ravens threw at A.J. Green as he still scored three touchdowns.
New York Jets owner Chris Johnson is trying to temper his giddiness as his club prepares to host the Miami Dolphins on Sunday.
Rams coach Sean McVay, whose power of recall was on full display in a recent Bleacher Report video, explained on Thursday his ability to remember plays: "I have no life. Other than I love football."
On Sunday, Saquon Barkley and Ezekiel Elliott will take the field as opponents for the first time since they met in a Big 10 clash in 2015.
Andy Dalton has high praise for A.J. Green after he catches three touchdowns against Baltimore.
A.J. Green catches three passes in the first half, all for touchdowns, and burns the Ravens' Tavon Young on two of them.