Hamilton went 5 of 9 from 3-point range and 7 of 11 overall and made all six of his free throws. Blackston was 10 of 11 from the field. Iwin Ellis and J.D. Wallace had 10 points apiece for the Panthers (3-11) and Dennis Jones had eight points and 10 assists.
Prairie View A&M shot 70 percent (21 of 30) in the first half with eight 3-pointers. Hamilton had 22 points and Blackston 18 as the Panthers opened a 59-32 lead over the Bulldogs, who shot 52 percent.
The lead reached 40 less than five minutes into the second half. All 11 players scored for the Panthers.
Isaiah Lopez had 12 points for Jarvis Christian.
North Carolina dealing with injuries entering Wake Forest matchup
Coach Roy Williams said Nassir Little did half-court work Thursday for about 30 minutes. Team spokesman Steve Kirschner said Little did more at Friday's practice, but the freshman's status would depend on how his ankle responds Saturday.
No. 18 Kansas State puts win streak up against No. 23 Iowa State
No. 23 Iowa State travels to No. 18 Kansas State for the biggest game on the Big 12 Conference's Saturday schedule.
No. 3 Gonzaga takes 15-game win streak to San Diego
Gonzaga has been so dominant in West Coast Conference play that a 13-point victory no longer feels impressive.