Pep Guardiola took Barcelona to the next level by urging them to always work hard. In Sunday's defeat, Real Betis worked much, much harder.
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After becoming the first coach to inflict a home defeat on Barcelona in 26 months, Real Betis manager Quique Setien's stock has never been higher.
Real Betis became the first side to win in the league at Barca in over two years -- a run stretching 42 games -- leaving with a 4-3 victory.
Lionel Messi made a scoring return to action following a broken arm but could not stop Barcelona suffering a surprise defeat at home to Real Betis.
Real Betis stunned AC Milan with a 2-1 win at the San Siro in Europa League group play on Thursday.
Giovani Lo Celso opened the scoring for the La Liga side in the 12th minute, but Suso ensured the points would be shared just after the hour mark.
Atletico Madrid defeated Real Betis 1-0 in a tight game on Sunday through a second-half strike from forward Angel Correa.
Real Betis' home league game against Athletic Bilbao on Sunday evening will be postponed, but Valencia and Levante were forced to play in high heat.
Joaquin, Iago Aspas and Jose Luis Morales have all been overlooked by bigger clubs, and now they are making magic in their backyards.
Veteran Real Betis midfielder Joaquin Sanchez came off the bench to score the only goal to give his side a 1-0 win over city rivals Sevilla.
Real Betis have signed midfielder Giovani Lo Celso on a season-long loan from Paris Saint-Germain with an option to buy the Argentina international.
Ernesto Valverde expressed his desire for Rafinha to stay at Barcelona but stopped short of ruling out a move to Real Betis.
Manchester City will likely only allow Oleksandr Zinchenko to move to Real Betis in a permanent deal and not on the loan they would like.
Cardiff City have signed midfielders Harry Arter and Victor Camarasa on season-long loan deals from Bournemouth and Real Betis.
William Carvalho has joined Real Betis from Sporting Lisbon, the La Liga outfit announced on their website on Friday.
Andres Guardado moved to Europe as a 20-year-old; 11 years later he is still there and set to captain Mexico in what will be his fourth World Cup.
Real Betis have announced the signing of Japan international Takashi Inui on a free transfer from La Liga rivals Eibar in interesting fashion.
Guardado has been a vital part of Mexico's national team under Juan Carlos Osorio, who is also facing fitness doubts over Hector Moreno.
Saul Niguez was denied by the crossbar as second-placed Atletico Madrid were held to a 0-0 La Liga draw by Real Betis.
Borussia Dortmund fans gave Marc Bartra an emotional farewell before Thursday's UEFA Europa League tie against Salzburg in the round of 16.