Nevada had five 40-plus-yard touchdowns. Daniel Brown returned an interception 42 yards, Mannix scored from 47 and 58 yards out, Jaxson Kincaide added a 73-yard grab and Romeo Doubs went 80 yards on a punt return.
It was the fifth-highest scoring output in Nevada's history and the most in its FBS era, which began in 1992.
Gangi was 16-of-26 passing for 342 yards and three TDs, and Mannix caught four passes for 132 yards. Doubs gave Nevada its first punt return touchdown since 2011.
Nevada scored 23 unanswered points for a 23-9 lead and it was 30-19 at halftime before the Wolf Pack took control with 42 straight points.
Touchdowns on six straight drives put Nevada ahead 58-19.
Happy with how Tua Tagovailoa and Jalen Hurts have handled split quarterback duties this season, Alabama coach Nick Saban told ESPN's Chris Low on Thursday that he plans to use both players for the remainder of the season.
Baker Mayfield pulls off a trick play, where he catches a 2-point conversion, similar to a play he executed for a touchdown in the 2018 Rose Bowl.
Ryquell Armstead ran for 108 yards and a touchdown, the Temple defense scored on two of its five turnovers and the Owls beat Tulsa 31-17 on Thursday night in an American Athletic Conference opener for both teams.
Tulsa QB Luke Skipper is stripped from behind by Temple's Sam Franklin and teammate Chapelle Russell recovers it to seal the win.
Tulsa's Corey Taylor II runs in a five-yard touchdown to shrink Tulsa's deficit to 28-17.
Down 28-10 early in the fourth, Cooper Edmiston intercepts Temple QB Anthony Russo to begin a Tulsa scoring drive.