Nevada had five 40-plus-yard touchdowns. Daniel Brown returned an interception 42 yards, Mannix scored from 47 and 58 yards out, Jaxson Kincaide added a 73-yard grab and Romeo Doubs went 80 yards on a punt return.
It was the fifth-highest scoring output in Nevada's history and the most in its FBS era, which began in 1992.
Gangi was 16-of-26 passing for 342 yards and three TDs, and Mannix caught four passes for 132 yards. Doubs gave Nevada its first punt return touchdown since 2011.
Nevada scored 23 unanswered points for a 23-9 lead and it was 30-19 at halftime before the Wolf Pack took control with 42 straight points.
Touchdowns on six straight drives put Nevada ahead 58-19.
Campbell's 1-yd TD puts Buckeyes on the board
Ohio State's Parris Campbell finds the end zone to score first against Michigan State.
WVU VS TCU
Wildcats humbled by veteran's selfless act
Head coach Mark Stoops talks about the respect he has for veteran and Kentucky fan, Matthew Bradford.
Incredible one-handed catch leads to SMU score
Mustangs wide receiver James Proche makes an incredible one-handed, diving catch to set up a SMU TD by Braeden West.
Morgan catches 2nd TD to give Nebraska lead
Adrian Martinez connects with Stanley Morgan Jr. for the second time on a 30+ yard touchdown, giving Nebraska the lead 21-14.
TCU fumble sets Mountaineers up with good field position
TCU's Kennedy Reed fumbles on a kick return and Exree Loe recovers for West Virginia on TCU's 17-yard line.